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Hapenxin 500
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Hapenxin 500





COMPOSITION
Cephalexin .............................................. 500 mg
Excipients q.s......................................... 1 capsule
(Wheat starch, talc powder, magnesium stearate)
DOSAGE FORM
Capsules
PRESENTATION
Box of 1 bottle x 100 capsules. ; Bottle of 200 capsules.
Box of 10 blisters x 10 capsules. ; Bottle of 500 capsules.
ACTIONS
Hapenxin with the active ingredient Cephalexin - a cephalosporin antibiotic - has a bactericidal property by inhibition of bacterial cell wall synthesis in both gram-positive and gram-negative bacteria. Hapenxin is resistant to the action of penicillinase; therefore, it acts against strains of penicillin-resistant staphylococcus aureus and most of ampicillin-resistant E.coli.
Hapenxin is almost completely absorbed, even in the presence of food; it is not affected by gastrointestinal tract diseases e.g. partial gastrectomy, achlorhydria, jaundice or diverticulosis (duodenal or jejunal). Hapenxin is excreted in the urine at high concentration; it is also used for prophylaxis of recurrent urinary tract infections.
INDICATIONS
Treatment of diseases:
- Respiratory tract infections: bronchitis, surinfectious bronchiectasia.
- ENT infections: sinusitis, mastoiditis, tonsillitis, pharyngitis, particularly rhinopharyngeal infections caused by streptococci, otitis media. Dental infections.
- Skin and skin structure, soft tissue, and bone infections.
- Genitourinary tract infections: acute and chronic pyelonephritis, cystitis, acute prostatitis. Gonorrhoea and syphilis (in cases where penicillin is unsuitable)
- Obstetric and gynaecological infections.
Prophylaxis of recurrent urinary tract infections. For replacement of penicillin prophylaxis in patients with cardiopathy, who are undergoing dental treatment.
CONTRAINDICATIONS
Hypersensitivity to cephalosporins and penicillins.
PRECAUTIONS
Patients with renal impairment.
Pregnancy: experimental studies and clinical experiences show no evidence of foetus toxicity or monster; however, cephalexin should be o­nly given to pregnant women if really necessary.
Lactation period: cephalexin concentration in breast milk is very low. However, it is advisable to discontinue provisionally breastfeeding during taking cephalexin.
Prolonged use of Hapenxin may cause drug-fast bacterial surinfections.
INTERACTIONS
Concomitant administration of cephalosporin at high doses with aminoglycoside or with diuretics may damage renal function. Probenecid may increase and prolong the plasma cephalosporin concentration and toxicity.
ADVERSE EFFECTS
Rarely: nausea, vomiting, diarrhoea, anorexia, abdominal pains, rashes, urticaria, dizziness, fatigue, headache.
Inform your physician about any adverse effects occur during the treatment.
DOSAGE & ADMINISTRATION
Adults and children > 12 years of age:
Oral dose of 1- 2 capsules x 3 - 4 times daily.
Or as directed by the physician.Read the directions carefully before use.
Consult the physician for more information.
This drug is for prescriptions o­nly.
SHELF-LIFE
24 months from the manufacturing date.
STORAGE CONDITIONS
Store in cool, dry place; protected from light.
SPECIFICATIONS
Vietnamese Pharmacopoeia III, 2002.






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