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Clanoz
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Clanoz





COMPOSITION:

Loratadine .................................10 mg

Excipients q.s............................1 tablet

(Lactose, tapioca starch, PVP K30, avicel, magnesium stearate, aerosil).

DOSAGE FORM: Tablets.

PRESENTATION:

Box of 2 blisters x 10 tablets.

ACTIONS:

Clanoz contains the active ingredient - loratadine, which is a long-acting tricyclic anti-histamine agent. The drug is a selective peripheral H1-antagonist; it has no effect of abatement o­n central nervous. Loratadine helps to reduce the symptoms of allergic rhinitis, pruritus and urticaria due to histamine release. Loratadine belongs to second-generation H1-receptor antagonists. In comparison with the first-generation antihistamine drugs, loratadine does not cross blood-brain barrier and therefore does not cause drowsiness. The level of adverse effects of loratadine is lower than that of other second-generation antihistamine drugs. Therefore, loratadine is priorly chosen to treat allergic rhinitis or allergic urticaria.

Loratadine is rapidly absorbed after oral administration. Loratadine is about 97% bound to plasma proteins. The antihistamine effect of loratadine appears within 1 - 4 hrs, attains to maximum after 8 - 12 hrs, and lasts more than 24 hrs. Loratadine and its metabolites are excreted in the urine and faeces.

INDICATIONS: Treatment of symptoms associated with allergic rhinitis e.g. sneezing, runny nose, nasal itching; and allergic conjunctivitis.

Symptomatic treatment of allergic signs e.g. chronic urticaria and other dermatological allergies.

CONTRAINDICATIONS:

Hypersensitivity to loratadine or anycomponents of the drug.

PRECAUTIONS:

The dosage should be reduced in patients with severe hepatic impairment.

Use with caution in pregnant women, nursing mothers, and children < 2 years of age.

INTERACTIONS:

Ketoconazole, erythromycin, and cimetidine inhibit the metabolism of loratadine.

Use with caution in patients concomitantly treated with the drugs inhibiting the metabolism in the liver.

ADVERSE EFFECTS:

Fatigue, headache, drowsiness, dryness of mouth, dyspepsia, and allergies.

Inform your physician about any adverse effects occur during the treatment.

OVERDOSAGE:

Symptoms: drowsiness, tachycardia, headache. Palpitation andextrapyramidal symptom may occur in children.

Treatment: Treatment of signs and symptoms of Loratadine is symptomatic and supportive. Treatment should be carried out immediately after emergency. The treatment should be maintained if necessary. Induced emesis by Ipecac syrup. Following emesis, adsorption of any drugs remaining in the stomach may be attempted by the administration of activated charcoal. If vomiting is unsuccessful or contrainidication, gastric lavage should be performed together with using 0.9% sodium chloride. Loratadine is not cleared by hemodialysis.

DOSAGE & ADMINISTRATION:

Adults and children aged > 12 years:

Oral dose of 1 tablet o­nce daily.

Or as directed by the physician.

Read the directions carefully before use.

Consult the physician for more information.

Shelf-life: 36 months from the manufacturing date.

Storage conditions: Store in dry places, not exceeding 300C.

Specifications: Manufacturer's.






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