Hapacol cs day

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Barcode: 8935206094817
Description

COMPOSITION:

Paracetamol ....................... 650 mg

Phenylephrine HCl .................. 5 mg

Excipients q.s...................... 1 tablet

(Pregelatinized starch, wheat starch, erythrosine lake color, PVP K30, nipagin, Indigo carmine color, sodium starch glycolate, magnesium stearate, talc, aerosil)

DOSAGE FORM: Tablets

PRESENTATION: Box of 10 blisters x 10 tablets.

ACTIONS: Paracetamol is an analgesic - antipyretic agent by action on the hypothalamic heat-regulating center causing hypothermia. Paracetamol produces analgesia by elevation of the pain threshold. Paracetamol is rapidly and completely absorbed by the gastrointestinal tract, is metabolized predominantly by the liver and excreted by the kidney. Phenylephrine is a alpha 1 sympathomimetic agent with mainly direct effects on alpha 1-adrenoceptors producing vasoconstriction. Phenylephrine is topically vasoconstrictive, so it relieves nasal and sinusal congestion caused by cold.

INDICATIONS: For the treatment of symptoms: fever, coryza, nasal congestion caused by flu, cold.

CONTRAINDICATIONS: Hypersensitivity to any components of the drug.

Patients with hepatic impairment, glucose-6-phosphate dehydrogenase deficiency.

Children aged < 12 years.

Avoid administration of phenylephrine to patients with severe coronary arterial disease, severe hypertension, angiocardiopathy, hyperthyroidism, and in those receiving monoamine oxidase inhibitors.

PRECAUTIONS: Paracetamol may cause liver damage if you consume more alcoholic drinks.

Hapacol CS Day should be used with caution in patients receiving beta-adrenergic inhibitors.

PREGNANCE AND LACTATION: Use with caution in pregnant and breast-feeding women.

VEHICLE DRIVERS AND MACHINERY OPERATORS: No document has been reported.

INTERACTIONS: Long-term use of high-dose paracetamol mildly increases the anticoagulant effect of coumarin and indandion derivative.

Anticonvulsants (phenytoin, barbiturate, carbamazepin), isoniazide increase the hepatotoxicity of paracetamol.

Avoid combination of phenylephrine and MAOIs because of an increase in systemic effect of phenylephrine.

Tricyclic antidepressants, guanethidine, atropine sulphate, veratrum alkaloids by injection, digitalis may increase the hypertensive effect of phenylephrine.

ADVERSE EFFECTS: Paracetamol rarely causes adverse effects. Allergy, rash, nausea, vomiting have been sometimes reported; in some cases, paracetamol may induce pancytopenia, hypoleukemia, anemia. Prolonged or high-dose use of Hapacol CS Day has been reported to cause hepatic impairment (due to hepatolysis).

Phenylephrine may cause tachycardia, palpitation, anxiety, sleeplessness, hypertension.

Inform your physician about any adverse effects occur during the treatment.

OVERDOSAGE:

Paracetamol overdosage is due to a single-dose or repeated large dose ingestion (7.5 - 10 g daily for 1 - 2 days), or long-time ingestion.

In acute paracetamol overdosage, dose-dependent, potentially fatal hepatic necrosis is the most serious adverse effect. Symptoms of paracetamol overdosage include nausea, vomiting, abdominal pains, cyanosis on skin, mucosa, and nails.

The main detoxication therapy is gastric lavage. N-acetylcysteine is more effective if administered within 10 - 12 hours of overdosage, and remains its benefit within 24 hours if treated.

Toxic doses of phenylephrine may be greater than those of paracetamol. Symptoms of phenylephrine overdosage include hypertension, headache, convulsion, encephalorrhagia, palpitation. Treatment: Hypertension may be overcome by administration of alpha-adrenergic blockers.

DOSAGE & ADMINISTRATION: Adults and children aged > 12 years are given 1 tablet, 2 - 3 times daily. The interval between oral doses should be 4 to 6 hours. Do not exceed 6 tablets daily.

Or as directed by the physician.

Read the directions carefully before use.

Consult the physician for more information.

Shelf-life: 24 months from the manufacturing date.

Storage conditions: Store in dry places, not exceeding 300C.

Specifications: Manufacturer's.

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