Bisacodyl DHG

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Barcode: 8935206094244
Description

COMPOSITION:

Bisacodyl …………………………………………………… 5 mg

Excipients q.s ………………………………………. 1 tablet

(Lactose, avicel, wheat starch, magnesium stearate, talc, PVP K30, sodium starch glycolate, eudragit L 100, PEG 6000, yellow ferric oxide, tartrazine lake color).

DOSAGE FORM:

Enteric film coated tablets.

PRESENTATION:

Box of 4 blisters x 25 enteric film coated tablets.

 

ACTIONS:

Bisacodyl is a triarylmethane stimulant laxative. After hydrolyzed, it stimulates intestinal mucosa resulting in increased enterocinesia.

Bisacodyl is hydrolyzed by enzyme of intestinal mucosa to desacetylbisacodyl. Absorption from the gastro-intestinal tract is minimal; the small amount absorbed is excreted in the urine and bile as the glucuronide. By the analysis of bacteria, active ingredient, free diphenol is formed in the large intestine. Formula of bisacodyl is stable in the presence of gastric juice and small intestinal juice; so the film coated tablets Bisacodyl come the large intestine unabsorbed significantly and avoid circulation through liver and intestine.

Bisacodyl is poorly absorbed following oral administration, metabolized in the liver and excreted in the urine. Following oral administration, bisacodyl is eliminated after 6 - 8 hours.

INDICATIONS:

For treatment of constipation.

In bowel cleansing in pre- or postoperative care.

In preparation for x-ray and endoscopic examination.

CONTRAINDICATIONS:

States of abdominal surgery, ileus, scolecoiditis, rectal bleeding, gastro-enteritis.

Hypersensitivity to any components of the drug.

PRECAUTIONS:

Pregnant women, breast-feeding mothers.

Do not chew tablets.

Do not take tablets within 1 hour after taking antacids, milk.

Bisacodyl should not be used longer than 1 week unless directed by a physician.

INTERACTIONS:

For potassium-keeping diuretic or potassium supplement, Bisacodyl may reduce their effects during prolonged use.

Concurrent use of bisacodyl and antacids, H2 inhibitors, or milk within 1 hour is reported to cause irritated stomach and duodenum due to quick dissolution.

Bisacodyl decreases the concentration of digoxin; so the interval between bisacodyl and digoxin should be at least 2 hours.

ADVERSE EFFECTS:

Rarely: abdominal pains, nausea.

Inform your physician about any adverse effects occur during the treatment.

OVERDOSAGE:

Symptoms include lower abdominal pain associated with dehydration, particularly in the elderly and children.

Treatment: Inducing emesis or emptying stomach are advised. Maintain and monitor serum potassium. Anticoagulants may be used if necessary. Balance of humour in the elderly and children should be particularly concerned.

No specific antidote have been reported.

 

OVERDOSAGE & ADMINISTRATION:

Treatment of constipation:

Adults and children aged > 10 years orally take 1 to 2 tablets in the evening. A higher dose (3 to 4 tablets) is necessary.

Children aged < 10 years orally take 1 tablet in the evening.

Substitute for fecal enema:

Adults and children aged > 10 years orally take 2 tablets 5 mg in the evening. Then, 10 mg (1 suppository) rectally in the morning.

Children aged < 10 years orally take 1 tablet 5 mg in the evening. Then 1 rectal suppository 5 mg in the morning.

In preparation for x-ray and endoscopic examination.

Adults and children aged > 10 years orally take 2 tablets every evening for 2 consecutive days before x-ray.

Children aged < 10 years orally take 1 tablet every evening every evening for 2 consecutive days before x-ray.

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