Clanoz

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Antihistamines, allergic rhinitis treatment
Barcode: 8935206007930
Description

CLANOZ

COMPOSITION: Loratadine ..................................................... 10 mg
                   Excipients q.s............................................... 1 tablet
(Lactose, wheat starch, PVP K30, avicel, magnesium stearate, aerosil).
DOSAGE FORM: Tablets.
PRESENTATION: Box of 2 blisters x 10 tablets.
ACTIONS: Clanoz contains the active ingredient - loratadine, which is a long-acting tricyclic antihistamine with selective peripheral H1-receptor antagonistic activity; it has no effect of abatement on central nervous. Loratadine helps to reduce the symptoms of allergic rhinitis, pruritus and urticaria due to histamine release. Loratadine belongs to second-generation H1-receptor antagonists. In comparison with the first-generation antihistamine drugs, loratadine does not cross blood-brain barrier and therefore does not cause drowsiness. The level of adverse effects of loratadine is lower than that of other second-generation antihistamine drugs. Therefore, loratadine is priorly chosen to treat allergic rhinitis or allergic urticaria. Loratadine is rapidly absorbed after oral administration. Loratadine is about 97% bound to plasma proteins. The antihistamine effect of loratadine appears within 1 - 4 hrs, attains to maximum after 8 - 12 hrs, and lasts more than 24 hrs. Loratadine and its metabolites are excreted in the urine and faeces.
INDICATIONS: Treatment of symptoms associated with allergic rhinitis e.g. sneezing, runny nose, nasal itching; and allergic conjunctivitis. Symptomatic treatment of allergic signs e.g. chronic urticaria and other dermatological allergies.
CONTRAINDICATIONS: Hypersensitivity to loratadine or any components of the drug.
PRECAUTIONS: The dosage should be reduced in patients with severe hepatic impairment. Children aged less than 2 years. Loratadine causes a risk of dental caries; therefore, cleanse mouth and teeth carefully before taking the drug.
PREGNANCY AND LACTATION:
Pregnant women: The safe use of loratadine during pregnancy has not been established. Inform doctor if using loratadine during pregnancy. 
Nursing mothers: the drug may be excreted in human milk and may harm your infants. Do not use  loratadine during lactation without doctor’s advice.
VEHICLE DRIVERS AND  MACHINERY OPERATORS:  Cautions should be taken when driving vehicle or operating machinery because the drug can induce headache, vague.
INTERACTIONS: Increase in plasma concentrations of loratadine have been reported after concomitant use with ketoconazole, erythromycin or cimetidine. Use with caution in patients concomitantly treated with the drugs inhibiting the metabolism in the liver.
ADVERSE EFFECTS: Commonly: headache, dryness of mouth.
Occasionally: drowsiness, dryness in the nose and sneezing, conjunctivitis.
Rarely: depression, tachycardia, supraventricular tachyarrhythmias, palpitations,  nausea, menstrual irregularities, skin rash, urticaria, anaphylactic shock.
Inform your physician about any adverse effects occur during the treatment.
OVERDOSAGE:
Symptoms: drowsiness, tachycardia, headache. Palpitation and extrapyramidal symptoms may occur in children.
Treatment: Treatment of signs and symptoms of Loratadine is symptomatic and supportive. Treatment should be carried out immediately after emergency. The treatment should be maintained if necessary. Induced emesis by Ipecac syrup. Following emesis, adsorption of any drugs remaining in the stomach may be attempted by the administration of activated charcoal. If vomiting is unsuccessful or contrainidication, gastric lavage should be performed together with using 0.9% sodium chloride. Loratadine is not cleared by hemodialysis.
DOSAGE & ADMINISTRATION: Adults and children aged > 12 years: 1 tablet once daily.
Children aged from 2 to 12 years: Body weight > 30 kg: 1 tablet once daily.
        Body weight < 30 kg: ½ tablet once daily.
Individuals suffered from severe hepatic and renal impairment (creatinine      clearance < 30 ml/ min): initial dose of 1 tablet once every two days.
Or as directed by the physician.
Read the directions carefully before use.
Consult the physician for more information.
Shelf-life: 36 months from the manufacturing date.
Storage conditions: Store in dry places, not exceeding 30oC, protect from light.
Specifications: Manufacturer's.

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