Zinc
ZINC
COMPOSITION:
Zinc gluconate ......... 70 mg
Excipients q.s ...... 1 sachet
(Avicel, dicalcium phosphate, pregelatinized starch, PVP K30, aerosil, magnesium stearate, talc, sodium starch glycolate, HPMC, PEG 6000, titanium dioxide).
DOSAGE FORM: Film coated tablets.
PRESENTATION: Box of 10 blisters x 10 tablets.
PHARMACODYNAMICS:
Zinc is an essential mineral that is present in most of cells. A human body contains approximately 2 to 3 g of zinc found in bone, teeth, hair, skin, liver, muscle, white cells, and testicle. Zinc stimulates the activities of enzymes which are catalysts of biological reactions in the body. Zinc is necessary for a healthy immune system with possibility of anti-infections and flu prevention. Zinc helps to heal wounds quickly, stimulate the growth of new cells, and restore cells wounded by free radicals. Zinc is also essential for DNA synthesis, stimulates the metabolism of vitamin A and the activities of vision and central nervous system.
In addition, zinc supports the normal growth and development of foetus in womb and during their childhood and teenager.
Protracted diarrhoea states lose a significant amount of zinc. The reduction of zinc in the body delays the reproduction and restoration processes of structures and functions of intestinal mucosal cells resulting in extending the diarrhoea condition. Therefore, the supplement of zinc is able to reduce diarrhoea in patients with protracted diarrhoea.
PHARMACOKINETICS:
Absorption of zinc from the gastrointestinal tract is incomplete; bioavailability of dietary zinc is about 20 to 30%. Zinc is distributed throughout the body with the highest concentrations found in muscle, bone, skin, eye, and prostatic fluids. It is primarily excreted in the faeces; small amounts are lost in urine and perspiration.
INDICATIONS:
Combining with oral rehydration salts solution in regimen of protracted diarrhoea treatment (according to WHO recommendation).
Adding zinc to daily dietary.
Preventing and treating cases of zinc deficiencies: children with rickets, malnutrition, growth retardation, frequently gastrointestinal disturbances, anorexia, sleeplessness, crying at night, recurrent infections of skin, respiratory tract, gastrointestinal tract, dry skin, horn-thickness skin of head-legs, baldness, dystrophia unguium (wrinkles, white spots, slow growth), slow-healing wound, xerophthalmia, helcoma, nyctalopia.
Pregnant women (frequently vomiting) and nursing mothers, patients having an unbalanced dietary or going on a diet, patients providing ingestion by intravenous route.
CONTRAINDICATIONS:
Hypersensitivity to any components of the drug.
PRECAUTIONS:
Zinc should be used with caution in patients with progressive gastro-duodenal ulcer and acute vomiting.
PREGNANCY AND LACTATION:
The drug can be used for these subjects.
VEHICLE DRIVERS AND MACHINERY OPERATORS:
The drug does not affect the possibility of driving vehicles and operating machinery.
INTERACTIONS:
Tetracycline, ciprofloxacin, iron- and copper-containing preparations reduce the absorption of zinc.
ADVERSE EFFECTS:
A gastric upset feeling has been rarely reported; this condition (if any) disappears after using the drug for few days.
Informs your physician about any adverse effects occur during the treatment.
OVERDOSAGE:
In acute toxicity, zinc salt causes erosion due to the formation of zinc chloride under the effect of gastric acid. Treatment by giving milk, alkaline metal carbonates, or active charcoal to patients. Do not apply gastric lavage or emesis.
A prolonged use of zinc or zinc-contaminated dialysate will cause copper deficiency, leading to sideroblastic anemia, neutropenia. Zinc level in blood is reduced by the used of sodium calcium edetate.
DOSAGE & ADMINISTRATION:
Children aged < 6 years may be given ½ tablet daily.
Adults and children aged > 6 years are given 1 tablet daily.
Pregnant women and nursing mothers are given 2 tablets daily.
Zinc should be taken after meals.
Or as prescribed by the physician.
Keep out of the reach of children.
Read the directions carefully before use.
Consult the physician for more information.
The drug is for prescription only.
Shelf-life: 36 months from the manufacturing date.
Storage conditions: Store in dry places, not exceeding 300C, protect from light.
Specifications: Manufacturer's.