Fubenzon

COMPOSITION:

Mebendazole..................................................... 500 mg

Excipients q.s................................................ 1 tablet

(Mannitol, aspartame, chocolate flavor, orange E110 color, eurolake green color, erythrosine lake color, magnesium stearate, vanillin, PVP K30).

DOSAGE FORM: Chewable tablets.

PRESENTATION: Box of 1 blister x 1 chewable tablet.

ACTIONS:

Fubenzon contains the active ingredient - mebendazole, which is a benzimidazole broad-spectrum anthelmintic derivative. Mebendazole produces the high effect in the adult and larval stages of roundworm (Ascaris lumbricoides), threadworm (Enterobius vermicularis), whipworm (Tricuris trichiura), hookworm (Ancylostoma duodenale and Necator americanus), and Capillaria philippinensis. The drug also destroys the ova of roundworm and whipworm. The drug has been tried in high dose in the treatment of hydatid disease.

The drug interferes with the synthesis of tubular micro-structure, so inhibiting the generation of the worm. In addition, the drug inhibits the glucose uptake of the worm.

Oral bioavailability of the drug is < 20%. However, the drug’s absorption can be raised in the presence of fat-containing food. The drug is about 95% bound to plasma proteins. The drug is mainly metabolised in the liver and eliminated by the bile and the faeces.

INDICATIONS: For the treatment of common roundworm, hookworm, whipworm, pinworm, eelworm in single or mixed infections.

CONTRAINDICATIONS:

Hypersensitivity to any components of the drug. Pregnant women. Severe hepatic disease.

PRECAUTIONS: Fubenzon should not be used in children < 2 years of age.

INTERACTIONS: Concurrent treatment with Cimetidine may inhibit the metabolism of mebendazole in the liver, resulting in increased plasma concentrations of mebendazole. Concomitant use of mebendazole and phenytoin or carbamazepine reduces the plasma mebendazole concentration.

ADVERSE EFFECTS:

Unfrequently: dizziness, abdominal pain, diarrhea, cases of worm crawling out of the mouth and nose.

Rarely: rash, urticaria, angioedema, convulsion.

Inform your physician about any adverse effects occur during the treatment.

OVERDOSAGE: In the event of accidental overdosage, gastrointestinal complaints lasting up to a few hours may occur. Vomiting, purging, use of activated carbon should be induced.

DOSAGE & ADMINISTRATION:

The tablet is chewed before swallowing with a little water.

Adults and children aged > 2 years: one tablet (500 mg) as a single dose.

The same dosage should be periodically administered every 4 to 6 months.

Or as directed by the physician.

Read the directions carefully before use.

Consult the physician for more information.

Shelf-life: 36 months from the manufacturing date.

Storage conditions: Store in dry places, at temperature below 30⁰C.

Specifications: Manufacturer’s.