Piracetam 800
NENI 800
COMPOSITION:
Piracetam ........................................ 800 mg
Excipients q.s .................................. 1 caplet
(Croscarmellose sodium, magnesium stearate, aerosil, sepifilm LP770).
DOSAGE FORM: Film coated caplet.
PRESENTATION: Box of 3 blisters x 10 caplets.
PHARMACODYNAMICS:
Piracetam, a cyclic derivative of gamma-aminobutyric acid acts to improve learning ability and memory due to the effect on neurotransmitters including acetylcholine, noradrenaline, and dopamine. Piracetam can alter neurotransmission and improve the metabolic environment of neurons.
Piracetam experimentally acts to resist metabolic disorders associated with ischemia by enhancing brain resistance to hypoxic state. Piracetam also enhances the mobilization and consumption of glucose without depending on oxygen supply, facilitates glucose conversion into pentose and maintains the synthesis of cerebral energy.
In addition, piracetam reduces platelet aggregation and in the conditions where there is abnormal rigidity of red blood cells, piracetam can restore the ability to deform and pass the capillaries. The drug acts to resist myoclonus.
PHARMACOKINETICS:
Piracetam is rapidly and completely absorbed after oral administration. Bioavailability of piracetam is close to 100%. Plasma maximum concentrations are achieved after 30 minutes, and at 2-8 hours in cerebrospinal fluid. The absorption of piracetam is not affected in long-term therapy. Piracetam diffuses to all tissues and crosses both blood-brain and placental barrier. Piracetam highest concentrations were in the cerebral cortex, frontal, parietal and occipital lobes, in the cerebral cortex and in the basal ganglia. The half-life is 4-5 hours in blood and 6-8 hours in cerebrospinal fluid. The half-life is increased in renal insufficiency patients. Piracetam is eliminated unchanged via kidneys.
INDICATIONS:
Treatment of symptoms associated with dizziness, headache, and severe delirium.
Improvement in symptoms in the elderly suffering from memory decline, dizziness, a lack of concentration or of alertness, behaviour disorders, personal negligence, dementia.
Treatment of acute ischemia, alcoholism, sickle cell anemia.
Supportive treatment of dyslexia in children.
Supportive treatment of myoclonus of cortical origin.
CONTRAINDICATIONS:
Hepatic impairment, severe renal impairment. Huntington's disease.
PRECAUTIONS:
Patients with renal impairment; the elderly.
PREGNANCY AND LACTATION:
Piracetam should not be administered to pregnant women and nursing mothers.
EFFECTS ON ABILITY TO DRIVE AND USE MACHINES:
Piracetam does not affect the capability of driving vehicles and operating machinery.
INTERACTIONS:
Piracetam interacts with CNS stimulants, thyroid hormones, and warfarin.
ADVERSE EFFECTS:
Common: General disorders: fatigue. Gastrointestinal tract disorders: nausea, vomiting, diarrhea, abdominal pains, dyspepsia. Nervous system disorders: anxiety, irritability, headache, insomnia, drowsiness.
Rare: General disorders: dizziness. Nervous system disorders: tremor, sexual arousal.
Inform your physician about any adverse effects occur during the treatment.
OVERDOSAGE:
Piracetam is non-toxic even a very high dose. Special measures is not necessary in overdose.
DOSAGE & ADMINISTRATION:
Piracetam is used following oral administration.
Adults: 1 caplet x 3 times daily.
Or as directed by the physician.
Read the directions carefully before use.
Consult the physician for more information.
This drug is for prescriptions only.
Shelf-life: 36 months from the manufacturing date.
Storage conditions: Store in dry places, not exceeding 30oC, protect from light.
Specifications: Manufacturer's.